Soluble FAS Ligand Enhances Suboptimal CD40L/IL-21–Mediated Human Memory B Cell Differentiation into Antibody-Secreting Cells
Abstract
Differentiation of Ag-specific B cells into class-switched, high-affinity, Ab-secreting cells provides protection against invading pathogens but is undesired when Abs target self-tissues in autoimmunity, beneficial non-self-blood transfusion products, or therapeutic proteins. Essential T cell factors have been uncovered that regulate T cell-dependent B cell differentiation. We performed a screen using a secreted protein library to identify novel...
Paper Details
Title
Soluble FAS Ligand Enhances Suboptimal CD40L/IL-21–Mediated Human Memory B Cell Differentiation into Antibody-Secreting Cells
Published Date
Jul 15, 2021
Journal
Volume
207
Issue
2
Pages
449 - 458
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