Recombinant sclerostin inhibits bone formation in vitro and in a mouse model of sclerosteosis
Volume: 29, Pages: 134 - 142
Published: Jul 1, 2021
Abstract
Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised by excessive bone formation, is caused by absence of sclerostin, a negative regulator of bone formation that binds LRP5/6 Wnt co-receptors. Current treatment is limited to surgical management of symptoms arising from bone overgrowth. This study investigated the effectiveness of sclerostin replacement therapy in a mouse model of sclerosteosis. Recombinant wild...
Paper Details
Title
Recombinant sclerostin inhibits bone formation in vitro and in a mouse model of sclerosteosis
Published Date
Jul 1, 2021
Volume
29
Pages
134 - 142
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