The contribution of TFPIα to the hemostatic response to injury in mice

BackgroundTissue factor pathway inhibitor (TFPI) is an essential regulator of coagulation, limiting thrombin generation and preventing thrombosis. In humans and mice, TFPIα is the sole isoform present in platelets.ObjectiveHere, we asked whether TFPIα, because of its release from platelets at sites of injury, has a unique role in limiting the hemostatic response.MethodsTFPIα‐mutant (TfpiΔα/Δα) mice were generated by introducing a stop codon in...