Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment
Abstract
Immunotherapies for cancer, such as immune checkpoint blockade or adoptive T-cell transfer, can lead to a long-lasting clinical response. But the therapeutic response rate remains low on account of many tumors that have evolved sophisticated strategies to evade immune surveillance. Solid tumors are characterized by the highly acidic microenvironment, which may weaken the effectiveness of antitumor immunity. Here, we explored a promising...
Paper Details
Title
Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment
Published Date
Jun 22, 2021
Journal
Volume
28
Issue
10-11
Pages
1213 - 1224
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Notes
History