A proposed protocol of intravitreal injection of methotrexate for treatment of primary vitreoretinal lymphoma

Primary central nervous system lymphoma (PCNSL) is a non-Hodgkin lymphoma involving the brain with possible leptomeningeal and ocular involvement. This study aimed to evaluate the safety and efficacy of modified intravitreal injection regimen of methotrexate (MTX) for therapeutic management of vitreoretinal lymphoma. Forty human immunodeficiency virus (HIV)–negative Chinese patients with primary vitreoretinal lymphoma were included in this...