Screening for New Inhibitors of Glycine Transporter 1 and 2 by Means of MS Binding Assays
Abstract
A straightforward screening of a compound library comprising 2439 substances for the identification of new inhibitors for the neurotransmitter transporters GlyT1 and GlyT2 is described. Screening and full-scale competition experiments were performed using recently developed GlyT1 and GlyT2 MS Binding Assays. That way for both targets, GlyT1 and GlyT2, ligands were identified, which exhibited affinities (pKi values) in the low micromolar to...
Paper Details
Title
Screening for New Inhibitors of Glycine Transporter 1 and 2 by Means of MS Binding Assays
Published Date
Jul 28, 2021
Journal
Volume
16
Issue
19
Pages
3094 - 3104
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