Mathematical Modeling and Numerical Simulation of Atherosclerotic Plaque Progression Based on Fluid-Structure Interaction

Published on Aug 1, 2021in Journal of Mathematical Fluid Mechanics0.97
· DOI :10.1007/S00021-021-00598-8
Silvia Pozzi1
Estimated H-index: 1
(Polytechnic University of Milan),
Alberto Redaelli49
Estimated H-index: 49
(Polytechnic University of Milan)
+ 2 AuthorsPaolo Zunino28
Estimated H-index: 28
(Polytechnic University of Milan)
Source
Abstract
In this work we propose a mathematical and numerical model to describe the early stages of atherosclerotic plaque formation, which is based on the interaction of processes with different spatial and temporal scales. A fluid–structure interaction problem, used to describe the cardiovascular mechanics arising between blood and the artery wall, is coupled to a set of differential problems describing the evolution of solute concentrations. In order to manage the multiscale-in-space nature of the involved processes, we propose a suitable numerical strategy based on the splitting and sequential solution of the coupled problem. We present some preliminary numerical results and investigate the effects of geometry, model parameters and coupling strategy on plaque growth.
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