Inhibition of topoisomerase I shapes antitumor immunity through the induction of monocyte-derived dendritic cells
Abstract
Understanding the rationale of combining immunotherapy and other anticancer treatment modalities is of great interest because of interpatient variability in single-agent immunotherapy. Here, we demonstrated that topoisomerase I inhibitors, a class of chemotherapeutic drugs, can alter the tumor immune landscape, corroborating their antitumor effects combined with immunotherapy. We observed that topotecan-conditioned TC-1 tumors were occupied by a...
Paper Details
Title
Inhibition of topoisomerase I shapes antitumor immunity through the induction of monocyte-derived dendritic cells
Published Date
Nov 1, 2021
Journal
Volume
520
Pages
38 - 47
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