Efficacy of Sacubitril-Valsartan in Patients With Reduced Left Ventricular Ejection Fraction

Neurohormonal activation is a principal target of heart failure (HF) therapies. Augmentation of vasodilatory and natriuretic peptides through inhibition of neprilysin with the angiotensin receptor-neprilysin inhibitor (ARNI) is proven to reduce death and HF hospitalizations in patients with HF and reduced ejection fraction (HFrEF) compared with enalapril in the PARADIGM-HF. 1 McMurray JJ Packer M Desai AS Gong J Lefkowitz MP Rizkala AR Rouleau...