Nanomechanical sensor for rapid and ultrasensitive detection of tumor markers in serum using nanobody
Abstract
Early cancer diagnosis requires ultrasensitive detection of tumor markers in blood. To this end, we develop a novel microcantilever immunosensor using nanobodies (Nbs) as receptors. As the smallest antibody (Ab) entity comprising an intact antigen-binding site, Nbs achieve dense receptor layers and short distances between antigen-binding regions and sensor surfaces, which significantly elevate the generation and transmission of surface stress....
Paper Details
Title
Nanomechanical sensor for rapid and ultrasensitive detection of tumor markers in serum using nanobody
Published Date
Jun 29, 2021
Journal
Volume
15
Issue
2
Pages
1003 - 1012
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