Monitoring of the immunogenic response to Pfizer BNT162b2 mRNA COVID-19 vaccination in healthcare workers with Snibe SARS-CoV-2 S-RBD IgG chemiluminescent immunoassay.

Published on Jun 23, 2021in Clinical Chemistry and Laboratory Medicine3.595
· DOI :10.1515/CCLM-2021-0687
Gian Luca Salvagno62
Estimated H-index: 62
(University of Verona),
Brandon Michael Henry33
Estimated H-index: 33
(Cincinnati Children's Hospital Medical Center)
+ 3 AuthorsGiuseppe Lippi109
Estimated H-index: 109
(University of Verona)
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Abstract
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20213.14Vaccine
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#1Giuseppe Lippi (University of Verona)H-Index: 109
#2Brandon Michael Henry (Cincinnati Children's Hospital Medical Center)H-Index: 33
Last. Mario Plebani (UNIPD: University of Padua)H-Index: 105
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Although universal vaccination is one of the most important healthcare strategies for limiting SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) circulation and averting the huge number of hospitalizations and deaths due to coronavirus disease 2019 (COVID-19), significant inter-individual variability of COVID-19 vaccines' efficacies has been described, mostly due to heterogeneous immune response in recipients. This opinion paper hence aims to discuss aspects related to the opportunity...
3 CitationsSource
#1Andrea Padoan (UNIPD: University of Padua)H-Index: 21
#2Luigi Dall'Olmo (UNIPD: University of Padua)H-Index: 12
Last. Mario Plebani (UNIPD: University of Padua)H-Index: 105
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Abstract Background Vaccine-induced population immunity is a key global strategy to control coronavirus disease 2019 (COVID-19). The rapid implementation and availability of several COVID-19 vaccines is now a global health-care priority but more information about humoral responses to single- and double-dose vaccine is needed Methods 163 health care workers (HCW) of the Padua University Hospitals, who underwent a complete vaccination campaign with BNT162b2 vaccine were asked to collect serum samp...
14 CitationsSource
#1Andrea Padoan (UNIPD: University of Padua)H-Index: 21
#2Francesco BonfanteH-Index: 10
Last. Mario Plebani (UNIPD: University of Padua)H-Index: 105
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Objectives SARS-CoV-2 serology presents an important role in several aspects of COVID-19 pandemic. Immunoassays performances have to be accurately evaluated and correlated with neutralizing antibodies. We investigated the analytical and clinical performances of a SARS-CoV-2 RBD IgG assay, automated on a high throughput platform, and the correlation of the antibodies (Ab) levels with the plaque reduction neutralization (PRNT50) Ab titers. Methods A series of 546 samples were evaluated by SARS-CoV...
7 CitationsSource
#1Andrea Padoan (UNIPD: University of Padua)H-Index: 21
#2Francesco BonfanteH-Index: 10
Last. Mario Plebani (UNIPD: University of Padua)H-Index: 105
view all 11 authors...
Abstract Background SARS-CoV-2 serology presents an important role in understanding the virus epidemiology, in vaccine prioritization strategies and in convalescent plasma therapy. Immunoassays performances have to be accurately evaluated and correlated with neutralizing antibodies to be used as a surrogate measure of neutralizing activity. We investigate the analytical and clinical performance of a SARS-CoV-2 RBD IgG assay, automated on a high throughput platform, and the correlation of the ant...
6 CitationsSource
#1Giuseppe Lippi (University of Verona)H-Index: 109
#2Laura SciacovelliH-Index: 28
Last. Mario PlebaniH-Index: 105
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Cited By3
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#1Dewald Schoeman (UWC: University of the Western Cape)H-Index: 2
#2Burtram C. Fielding (UWC: University of the Western Cape)H-Index: 22
Over the past 18 years, three highly pathogenic human (h) coronaviruses (CoVs) have caused severe outbreaks, the most recent causative agent, SARS-CoV-2, being the first to cause a pandemic. Although much progress has been made since the COVID-19 pandemic started, much about SARS-CoV-2 and its disease, COVID-19, is still poorly understood. The highly pathogenic hCoVs differ in some respects, but also share some similarities in clinical presentation, the risk factors associated with severe diseas...
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#1Hidetsugu Fujigaki (RMIT: RMIT University)H-Index: 12
#2Yasuko Yamamoto (RMIT: RMIT University)H-Index: 20
Last. Saya Moriyama (NIH: National Institutes of Health)H-Index: 2
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BACKGROUND: To fight severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), mass vaccination has begun in many countries. To investigate the usefulness of a serological assay to predict vaccine efficacy, we analyzed the levels of IgG, IgM, and IgA against the receptor binding domain (RBD) of SARS-CoV-2 in the sera from BNT162b2 vaccinated individuals in Japan. METHODS: This study included 219 individuals who received two doses of BNT162b2....
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#1Mario Plebani (UNIPD: University of Padua)H-Index: 105
#2Chiara CosmaH-Index: 16
Last. Andrea Padoan (UNIPD: University of Padua)H-Index: 21
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