Obesity, Adiposity, and Risk of Symptomatic Gallstone Disease According to Genetic Susceptibility

Adiposity has been consistently associated with gallstone disease risk. We aimed to characterize associations of anthropometric measures (body mass index [BMI], recent weight change, long-term weight change, waist circumference, and waist-to-hip ratio) with symptomatic gallstone disease according to strata of gallstone disease polygenic risk score (PRS).We conducted analysis among 34,626 participants with available genome-wide genetic data...