The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome
Volume: 25, Issue: 16, Pages: 8047 - 8061
Published: Jun 24, 2021
Abstract
Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanisms remain unclear. We sequenced the alternative P2 promoter driving intestinal SLC6A4 expression and identified single nucleotide polymorphisms (SNPs) that were associated with IBS in a discovery...
Paper Details
Title
The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome
Published Date
Jun 24, 2021
Volume
25
Issue
16
Pages
8047 - 8061
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