An in-host HIV-1 infection model incorporating quiescent and activated CD4<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si39.svg"><mml:msup><mml:mrow /><mml:mo>+</mml:mo></mml:msup></mml:math> T cells as well as CTL response

A mathematical model is proposed to capture the implication of quiescent and activated CD4+ T cells as well as the cytotoxic T lymphocyte (CTL) response on HIV-1 infection in an early stage. It underlies the different mechanisms behind the productive and latent infection, whereby virion-cell contact, cell-cell contact, immune response, slow-kinetic viral reverse transcription in quiescent cells, lytic death, pyroptosis, and virus survival play...