Computational Analysis of Virtual Echocardiographic Assessment of Functional Mitral Regurgitation for Validation of Proximal Isovelocity Surface Area Methods

•Patient-specific computer models of MR were created for validation of PISA methods. •PISA area is subject to underestimation due to the Doppler angle effect. •Regurgitant flow rate is subject to overestimation due to flow direction angle. •Integrated PISA is more robust than peak PISA for RV quantification. Background Mitral regurgitation (MR) quantification by the proximal isovelocity surface area (PISA) method remains challenging. Using...