Itacitinib prevents xenogeneic GVHD in humanized mice
Abstract
We assessed the impact of the Janus Kinase (JAK) 1 inhibitor itacitinib on xenogeneic graft-versus-host disease (xGVHD). XGVHD was induced by i.v. injection 20 × 106 human peripheral blood mononuclear cells (hPBMC) in NSG mice on day 0. Itacitinib (3 mg, ≈120 mg/kg) or methylcellulose was administered by force-feeding twice a day from day 3 to day 28. Mice were followed for xGVHD score and survival. In addition, human T-cell engraftment and as...
Paper Details
Title
Itacitinib prevents xenogeneic GVHD in humanized mice
Published Date
Jun 25, 2021
Journal
Volume
56
Issue
11
Pages
2672 - 2681
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