Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders
Abstract
As B cells differentiate into antibody-secreting cells (ASCs), short-lived plasmablasts (SLPBs) are produced by a primary extrafollicular response, followed by the generation of memory B cells and long-lived plasma cells (LLPCs) in germinal centers (GCs). Generation of IgG4 antibodies is T helper type 2 (Th2) and IL-4, -13, and -10-driven and can occur parallel to IgE, in response to chronic stimulation by allergens and helminths. Although IgG4...
Paper Details
Title
Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders
Published Date
Jun 17, 2021
Journal
Volume
12
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