A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission
Abstract
Endosome fission is essential for cargo sorting and targeting in the endosomal system. However, whether organelles other than the endoplasmic reticulum (ER) participate in endosome fission through membrane contacts is unknown. Here, we characterize a Golgi-derived vesicle, the SEC14L2 compartment, that plays a unique role in facilitating endosome fission through ternary contacts with endosomes and the ER. Localized to the ER-mediated endosome...
Paper Details
Title
A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission
Published Date
Jun 28, 2021
Journal
Volume
23
Issue
7
Pages
782 - 795
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