Histone H2B ubiquitination mediated chromatin relaxation is essential for the induction of somatic cell reprogramming

Objectives Cell reprogramming has significant impacts on their potential application in regenerative medicine. Chromatin remodelling plays a very important role in cell reprogramming, but its underlying mechanism remains poorly understood. Materials and methods RNA‐seq, quantitative RT‐PCR and western blot analysis were applied to study the role of RNF20 and H2B ubiquitination during mouse somatic cell reprogramming. Chromatin structure and the...