Reconstruction of the cervical spinal cord based on motor function restoration and mitigation of oxidative stress and inflammation through eNOS/Nrf2 signaling pathway using ibuprofen-loaded nanomicelles

Motor disfunction and oxidative and inflammatory stress after spinal cord injuries (SCIs) occur as a result of primary mechanical damage and secondary degeneration process. In the present study, we aimed to examine the protective effect of fabricated ibuprofen- polyethylene glycol (PEG)/polylactide acid (PLA) diblock copolymer nanomicelles on reconstruction of motor-evoked potential (MEP) of cervical spinal cord, the posterior limb function, ROS...