ATF3 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an N⁶-Methyladenosine-Based Epitranscriptomic Mechanism

Tamoxifen has been used for years for treating estrogen receptor-positive breast cancer; drug resistance, however, constitutes one of the main challenges for this therapy. We found that the protein expression level of ATF3 is significantly higher in tamoxifen-resistant (TamR) MCF-7 cells than the corresponding parental cancer cells. In addition, ATF3 protein expression is positively correlated with the resistance of TamR MCF-7 cells to...