Deletion of the miR‐25/93/106b cluster induces glomerular deposition of immune complexes and renal fibrosis in mice

Volume: 25, Issue: 16, Pages: 7922 - 7934
Published: Jul 1, 2021
Abstract
IgA nephropathy (IgAN), the most common form of primary glomerulonephritis, is caused by immune system dysfunction and affects only the kidneys. miRNA was involved in IgAN, in which their roles are still unknown. Herein, we found increased glomerular medulla size, proteinuria, kidney artery resistance, kidney fibrosis and immune complex deposition in 5-month miR-25/93/106b cluster knockout (miR-TKO) mice. In vitro, the inhibition of miR-25...
Paper Details
Title
Deletion of the miR‐25/93/106b cluster induces glomerular deposition of immune complexes and renal fibrosis in mice
Published Date
Jul 1, 2021
Volume
25
Issue
16
Pages
7922 - 7934
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