Internal medicine

Phenotype

Exome sequencing

Population

Haploinsufficiency

Biology

Gene

Interquartile range

Immunology

Sepsis

Arthritis

Macrophage activation syndrome

Systemic inflammatory response syndrome

Mutation

Genetics

Medicine

Environmental health

Journal of Allergy and Clinical Immunology

Multisystem inflammatory syndrome in children (MIS-C) is a pediatric complication of severe acute respiratory syndrome coronavirus 2 infection that is characterized by multiorgan inflammation and frequently by cardiovascular dysfunction. It occurs predominantly in otherwise healthy children. We previously reported haploinsufficiency of suppressor of cytokine signaling 1 (SOCS1), a negative regulator of type I and II interferons, as a genetic risk factor for MIS-C.

Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)