Phenolic compounds from Ficus hispida L.f. as tyrosinase and melanin inhibitors: Biological evaluation, molecular docking, and molecular dynamics

Eleven known phenolic compounds 1–11 were isolated from the MeOH extract of the fruits of Ficus hispida L.f. (Moraceae), all of which have been investigated inhibitory activities of melanin and tyrosinase in vitro. Compounds 1, 2, and 5–8 exhibited potent melanin inhibitory activities against B16F10 melanoma cells, especially 5,7-dihydroxy-4′-methoxy-3′-(3-methyl-2-hydroxybuten-3-yl)isoflavone (2) showed superior inhibitory effect with no or...