Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors

Ferroptosis is a new type of cell death, which involves central neuronal system. Inhibition of ferroptosis is a promising strategy to prevent and treat neurological diseases. Thirteen phloroglucinols (1−13) were obtained from the whole plants of Hypericum japonicum. Of them, compounds 1–3 are new ones. Their structures were elucidated by extensive analysis of spectroscopic data and X-ray diffraction. All the isolates were evaluated for their...