p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
Abstract
Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and requires active fibroblast growth factor 4 (FGF4) signaling. Previously, we identified a role for p38 mitogen-activated protein kinases (p38-MAPKs) during PrE differentiation, but the underlying mechanisms have remained unresolved. Here, we report an early blastocyst...
Paper Details
Title
p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
Published Date
Jun 25, 2021
Journal
Volume
4
Issue
1
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