Early-onset neonatal sepsis: Finding a needle in a haystack

Sepsis is an uncommon disease, especially in infants ≥35 weeks' gestation when the incidence in the general population is 0.5-1.0/1000 live births. Although the incidence is higher in symptomatic infants and those with risk factors, sepsis evaluations are far more common than infants with proven sepsis. How can practitioners identify the one baby with sepsis from the many infants with risk factors or clinical signs (finding a needle in a...