Monodispersed cyclodextrin-based nanocomplex of neuropeptide Y for targeting MCF-7 cells using a central composite design

The present study aimed to complex neuropeptide Y with hydroxypropyl β-cyclodextrin (HPβ-CD) and optimize using central composite design with different levels of neuropeptide Y and HPβ-CD. The validated inclusion nanocomplex (formulation CN) showed monodispersed particle size of 330.019 ± 4.08 nm, % entrapment efficiency of 84.68 ± 5.47 and in-vitro neuropeptide Y release from the complex of 85.16 ± 6.13% for 24 h. Formulation CN was found to be...