Collagen XXIV Null Mouse Bones Are Not Osteoporotic Due to an Insufficiency of Osteoblastogenesis Factors

Collagen XXIV is a non‐traditional member of the fibrillar collagens expressed in bone. The density of wild type (WT) and knock out (KO) mouse femurs was analyzed by micro CT. Femurs of 3 and 5 month old null mice were found to be osteoporotic as compared to those of WT mice. As a first avenue of investigation to understand this, the expression levels of mRNAs involved in the regulation of osteoblastogenesis were examined. cDNA was made from 7...