Glycine substitution of α1F64 residue at the loop D of GABAA receptor impairs gating – Implications for importance of binding site-channel gate linker rigidity

Volume: 192, Pages: 114668 - 114668
Published: Oct 1, 2021
Abstract
GABAA receptors (GABAARs) play a crucial role in mediating inhibition in adult mammalian brains. In the recent years, an impressive progress in revealing the static structure of GABAARs was achieved but the molecular mechanisms underlying their conformational transitions remain elusive. Phenylalanine 64 (α1F64) is located at the loop D of the orthosteric binding site of GABAAR and was found to directly interact with GABA molecule. Mutations of...
Paper Details
Title
Glycine substitution of α1F64 residue at the loop D of GABAA receptor impairs gating – Implications for importance of binding site-channel gate linker rigidity
Published Date
Oct 1, 2021
Volume
192
Pages
114668 - 114668
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.