Immune control of Mycobacterium tuberculosis is dependent on both soluble TNFRp55 and soluble TNFRp75

Tuberculosis presents a global health challenge, and tumour necrosis factor (TNF) signalling is required for host immunity against Mycobacterium tuberculosis ( Mtb ). TNF receptor shedding, however, compromises effective immunity by reducing bioactive TNF through the formation of inactive complexes. In this study, we first compared the effect of total soluble TNF receptors using a transgenic p55 ΔNS /p75 −/− murine strain on host protection...