Design of acid‐activated cell‐penetrating peptides with nuclear localization capacity for anticancer drug delivery
Abstract
Camptothecin (CPT), a DNA-toxin drug, exerts anticancer activity by inhibiting topoisomerase I. Targeted delivery of CPT into the cancer cell nucleus is important for enhancing its therapeutic efficiency. In this study, a new type of acid-activated cell-penetrating peptide (CPP) with nuclear localization capacity was constructed by conjugating six histidine residues and a hydrophobic peptide sequence, PFVYLI, to the nuclear localization sequence...
Paper Details
Title
Design of acid‐activated cell‐penetrating peptides with nuclear localization capacity for anticancer drug delivery
Published Date
Jun 7, 2021
Journal
Volume
27
Issue
10
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