Persistently Elevated Heart Rate Alters EEG Patterns and Locomotor Behavior in Mice

Descending autonomic signaling, traveling from central stations, contributes to regulating heart rate (HR) in response to environmental demands. However, whether and how cardiac rhythm influences central functions in a “bottom-up modality” remains poorly understood. Here, we tested whether persistently elevated HR in mice affects the brain-heart bidirectional communication, the electroencephalographic (EEG) patterns, and behavior. To this end,...