Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma
Abstract
Glioblastoma (GBM) is the deadliest of all brain cancers in adults. The current standard-of-care is surgery followed by radiotherapy and temozolomide, leading to a median survival time of only 15 months. GBM are organized hierarchically with a small number of glioma-initiating cells (GICs), responsible for therapy resistance and tumor recurrence, suggesting that targeting GICs could improve treatment response. ONC201 is a first-in-class...
Paper Details
Title
Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma
Published Date
Aug 1, 2021
Journal
Volume
161
Pages
140 - 147
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