Cytomegalovirus subverts macrophage identity
Abstract
Cytomegaloviruses (CMVs) have co-evolved with their mammalian hosts for millions of years, leading to remarkable host specificity and high infection prevalence. Macrophages, which already populate barrier tissues in the embryo, are the predominant immune cells at potential CMV entry sites. Here we show that, upon CMV infection, macrophages undergo a morphological, immunophenotypic, and metabolic transformation process with features of stemness,...
Paper Details
Title
Cytomegalovirus subverts macrophage identity
Published Date
Jul 1, 2021
Journal
Volume
184
Issue
14
Pages
3774 - 3793.e25
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