Genetically Determined Gut Microbiome Abundance and 2-Year Changes in Central Adiposity and Body Composition: The POUNDS Lost Trial

Growing evidence has linked gut microbiome abundance with adiposity regulation. A recent genome-wide association study (GWAS) identified 20 genetic variants related to gut microbiome abundance. We aimed to examine whether the genetically determined gut microbiome abundance was associated with 2-year changes in adiposity and body composition among overweight and obese individuals in weight-loss diet interventions. The study included 692...