Assessing safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic (GEP) and thoracic neuroendocrine tumors (NETs): The phase II LOLA trial.

TPS4167 Background: Well-differentiated (WD) NETs are a group of rare neoplasms with limited therapeutic options. New combinations of somatostatin analogs (SSAs) and investigational drugs are warranted to improve clinical outcomes. Cabozantinib (CAB) is an orally administered inhibitor of multiple tyrosine kinases, including c-MET and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), with a pivotal role in NET pathogenesis. The biological...