A remotely controlled NIR-II photothermal-sensitive transgene system for hepatocellular carcinoma synergistic therapy
Abstract
Photothermal therapy (PTT) exhibits an excellent therapeutic effect in cancer treatment, but some cancers are still facing rapid recurrence due to the presence of heat-resistant cells, which express heat shock proteins (HSP) to defend against hyperthermia. Inspired by optogenetics, we firstly designed a caged TNF-related apoptosis-inducing ligand (TRAIL) expressing plasmid under HSP70 protomer (HSP70-TRAIL) as the thermal-activated gene therapy...
Paper Details
Title
A remotely controlled NIR-II photothermal-sensitive transgene system for hepatocellular carcinoma synergistic therapy
Published Date
Jan 1, 2021
Volume
9
Issue
25
Pages
5083 - 5091
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