Trop-2 inactivates E-cadherin and drives colon cancer metastasis.
Volume: 39, Issue: 15_suppl, Pages: e15576 - e15576
Published: May 20, 2021
Abstract
e15576 Background: Metastatic diffusion is the biggest hurdle for colon cancer (CRC) cure and the identification of decisive drivers of CRC metastasis is an urgent need in CRC care. Methods: The expression of target molecules in primary tumors and metastases was systematically assessed by DNA array and IHC analysis. Cell-cell adhesion capacity was quantified in 2D cell cultures and in HCT116 CRC cell spheroids. Pro-metastatic impact of wtTrop-2...
Paper Details
Title
Trop-2 inactivates E-cadherin and drives colon cancer metastasis.
Published Date
May 20, 2021
Journal
Volume
39
Issue
15_suppl
Pages
e15576 - e15576
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