C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.

Volume: 566, Pages: 197 - 203
Published: Jun 15, 2021
Abstract
Maytansinoids, the chemical derivatives of Maytansine, are commonly used as potent cytotoxic payloads in antibody-drug conjugates (ADC). Structure-activity-relationship studies had identified the C3 ester side chain as a critical element for antitumor activity of maytansinoids. The maytansinoids bearing the methyl group at C3 position with D configuration were about 100 to 400-fold less cytotoxic than their corresponding L-epimers toward various...
Paper Details
Title
C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.
Published Date
Jun 15, 2021
Volume
566
Pages
197 - 203
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