Investigating the physical characteristics and cellular interplay on 3D-printed scaffolds depending on the incorporated silica size for hard tissue regeneration

Silica has been widely used in bone tissue regeneration which is known to increase the bone mineral density and reduce bone resorption. In this study, surface modified silica particles with different sizes (100, 500, and 800 nm) were incorporated with polycaprolactone (PCL) to study the influence of silica particle size on physical and biological properties. Controversial results were observed between the physical and biological properties. In...