Three-dimensional folding dynamics of the Xenopus tropicalis genome
Abstract
Animal interphase chromosomes are organized into topologically associating domains (TADs). How TADs are formed is not fully understood. Here, we combined high-throughput chromosome conformation capture and gene silencing to obtain insights into TAD dynamics in Xenopus tropicalis embryos. First, TAD establishment in X. tropicalis is similar to that in mice and flies and does not depend on zygotic genome transcriptional activation. This process is...
Paper Details
Title
Three-dimensional folding dynamics of the Xenopus tropicalis genome
Published Date
Jun 7, 2021
Journal
Volume
53
Issue
7
Pages
1075 - 1087
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