Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
Abstract
Recently, we involved the carbohydrate-binding protein Galectin-3 (Gal-3) as a druggable target for KRAS-mutant-addicted lung and pancreatic cancers. Here, using glioblastoma patient-derived stem cells (GSCs), we identify and characterize a subset of Gal-3 high glioblastoma (GBM) tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis. Using both genetic and pharmacologic inhibition of Gal-3, we showed a...
Paper Details
Title
Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
Published Date
Jun 10, 2021
Journal
Volume
4
Issue
1
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