Sex‐specific role for prefrontal cortical protein interacting with C kinase 1 in cue‐induced cocaine seeking
Abstract
Disruption of prefrontal glutamate receptor interacting protein (GRIP), which anchors GluA2‐containing AMPA receptors (AMPARs) into the synaptic membrane, potentiates cue‐induced cocaine seeking in both males and females. Protein interacting with C kinase 1 (PICK1) plays an opposing role to that of GRIP, removing AMPARs from the synapse. Consistent with our hypothesis that disruption of PICK1 in the mPFC would lead to a decrease in...
Paper Details
Title
Sex‐specific role for prefrontal cortical protein interacting with C kinase 1 in cue‐induced cocaine seeking
Published Date
Jun 10, 2021
Journal
Volume
26
Issue
5
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