Comparative metabolomics and lipidomics study to evaluate the metabolic differences between first‐ and second‐generation mammalian or mechanistic target of rapamycin inhibitors

Volume: 35, Issue: 11
Published: Jun 23, 2021
Abstract
Mammalian or mechanistic target of rapamycin (mTOR) drives its fundamental cellular functions through two distinct catalytic subunits, mTORC1 and mTORC2, and is frequently dysregulated in most cancers. To treat cancers, developed mTOR inhibitors have been classified into first and second generations based on their ability to inhibit single (first-generation) and dual (second-generation) mTOR subunits. However, the underlying metabolic...
Paper Details
Title
Comparative metabolomics and lipidomics study to evaluate the metabolic differences between first‐ and second‐generation mammalian or mechanistic target of rapamycin inhibitors
Published Date
Jun 23, 2021
Volume
35
Issue
11
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