Twenty‐five years of biologicals in IBD: What´s all the hype about?
Abstract
Twenty-five years ago the field was revolutionized by the introduction of infliximab as the first hybrid anti-TNF-antibody. Subsequently, other humanized anti-TNFs were developed and marketed, followed by antibodies to new targets including integrins (vedolizumab) and interleukin 12/23 (ustekinumab). All these so-called biologicals were shown in registrational trials to induce remission superior to placebo but consistently were effective in only...
Paper Details
Title
Twenty‐five years of biologicals in IBD: What´s all the hype about?
Published Date
Jul 21, 2021
Journal
Volume
290
Issue
4
Pages
806 - 825
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