B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy

Volume: 164, Issue: 3, Pages: 507 - 523
Published: Jun 21, 2021
Abstract
Loss of the B2M gene is associated with tumour immune escape and resistance to immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer (NSCLC) patients and found that epigenetic downregulation of B2M is common. B2M-low tumours exhibit a suppressive immune microenvironment characterized by reduced...
Paper Details
Title
B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy
Published Date
Jun 21, 2021
Journal
Volume
164
Issue
3
Pages
507 - 523
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