Elevated soluble urokinase plasminogen activator receptor (suPAR) in COVID-19 patients.

Published on Jun 14, 2021in Clinical Chemistry and Laboratory Medicine3.595
· DOI :10.1515/CCLM-2021-0561
Giuseppe Lippi109
Estimated H-index: 109
(University of Verona),
Brandon Michael Henry33
Estimated H-index: 33
(Cincinnati Children's Hospital Medical Center),
Emmanuel J. Favaloro70
Estimated H-index: 70
(Westmead Hospital)
Sources
Abstract
📖 Papers frequently viewed together
2017
1 Author (Ville Jalkanen)
1 Citations
References18
Newest
#1David T Arnold (UoB: University of Bristol)H-Index: 15
#2Marie Attwood (North Bristol NHS Trust)H-Index: 5
Last. Fergus Hamilton (North Bristol NHS Trust)H-Index: 10
view all 12 authors...
INTRODUCTION COVID-19 has an unpredictable clinical course, so prognostic biomarkers would be invaluable when triaging patients on admission to hospital. Many biomarkers have been suggested using large observational datasets but sample timing is crucial to ensure prognostic relevance. The DISCOVER study prospectively recruited patients with COVID-19 admitted to a UK hospital and analysed a panel of putative prognostic biomarkers on the admission blood sample to identify markers of poor outcome. ...
2 CitationsSource
#1Buğra Kerget (Atatürk University)H-Index: 6
#2Ferhan KergetH-Index: 3
Last. Leyla Saglam (Atatürk University)H-Index: 14
view all 6 authors...
BACKGROUND COVID-19 is one of the most important health problems of this century, but our knowledge of the disease is still limited. In this study, we aimed to examine serum-soluble urokinase plasminogen activator receptor (suPAR) and kidney injury molecule 1 (KIM-1) levels based on the clinical course of COVID-19. MATERIALS AND METHODS Our study included 102 patients over the age of 18 who were diagnosed as having COVID-19 between September 2020 and December 2020 and a control group of 50 healt...
2 CitationsSource
#1Abderrahim Oulhaj (United Arab Emirates University)H-Index: 17
#2Ahmed R. Alsuwaidi (United Arab Emirates University)H-Index: 10
Last. Harald Sourij (United Arab Emirates University)H-Index: 1
view all 13 authors...
OBJECTIVE: To examine the association between plasma levels of the soluble urokinase plasminogen activator receptor (suPAR) and the incidence of severe complications of COVID-19. METHODS: 403 RT-PCR-confirmed COVID-19 patients were recruited and prospectively followed-up at a major hospital in the United Arab Emirates. The primary endpoint was time from admission until the development of a composite outcome, including acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admissio...
1 CitationsSource
#1Trishala MenonH-Index: 3
#2Rohit Sharma (Hamad Medical Corporation)H-Index: 4
Last. Zahoor AhmedH-Index: 1
view all 10 authors...
Background and objective The coronavirus disease 2019 (COVID-19) pandemic has become a global healthcare emergency The severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), the causative agent of COVID-19, has a wide range of clinical manifestations ranging from subclinical infection to multi-organ failure In addition to the respiratory system, COVID-19 also adversely affects the kidneys In this study, we aimed to measure the prevalence of acute kidney injury (AKI) in COVID-19 and its a...
7 CitationsSource
#1Bugra KergetH-Index: 1
Last. Leyla SaglamH-Index: 14
view all 6 authors...
Objective: COVID-19 is one of the most important health problems concerning the last century and our knowledge of the disease is still limited. In our study, we aimed to compare serum-soluble urokinase plasminogen activator receptor (suPAR) and kidney injury molecule-1 (KIM-1) level with clinical course in COVID-19 patients. Methods: Our study included 102 patients over the age of 18 who were diagnosed with Covid-19 between September 2020 and December 2020 by taking nasopharyngeal swap and using...
1 CitationsSource
#1Giuseppe Lippi (University of Verona)H-Index: 109
#2Fabian Sanchis-Gomar (University of Valencia)H-Index: 45
Last. Brandon Michael Henry (Cincinnati Children's Hospital Medical Center)H-Index: 33
view all 5 authors...
Patients with the severe form of coronavirus disease 2019 (COVID-19) have been frequently found to suffer from both arterial and venous thrombotic events due to the perpetuation of a hypercoagulable state. This phenomenon, termed COVID-19-associated coagulopathy, is now considered a major component of the pathophysiology of this novel infectious disease, leading to widespread thrombosis. While at first, the vascular insults may be limited to the pulmonary microvasculature, as the disease progres...
21 CitationsSource
#1Mingxiang HuangH-Index: 2
#2Linlin Li (FZU: Fuzhou University)H-Index: 3
Last. Longguang Jiang (FZU: Fuzhou University)H-Index: 14
view all 8 authors...
4 CitationsSource
#1Tariq U. Azam (UM: University of Michigan)H-Index: 6
#2Husam ShadidH-Index: 2
Last. Salim S. Hayek (UM: University of Michigan)H-Index: 30
view all 27 authors...
BACKGROUND: AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, and coagulation, and soluble urokinase plasminogen activator receptor (suPAR) has been identified as an immunologic risk factor for AKI. Whether suPAR is associated with COVID-19-related AKI is unknown. METHODS: In a multinational observational study of adult patients hospi...
22 CitationsSource
#1Zahava Vadasz (Rappaport Faculty of Medicine)H-Index: 15
#1Zahava Vadasz (Rappaport Faculty of Medicine)H-Index: 5
Last. Elias Toubi (Rappaport Faculty of Medicine)H-Index: 1
view all 3 authors...
5 CitationsSource
#1Fabian Braun (UHH: University of Hamburg)H-Index: 10
#2Marc Lütgehetmann (UHH: University of Hamburg)H-Index: 39
Last. Tobias B. Huber (UHH: University of Hamburg)H-Index: 68
view all 18 authors...
100 CitationsSource
Cited By0
Newest