Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry

Published: Jun 14, 2021
Abstract
Summary Primordial germ cells (PGCs) are induced in the embryo by signals, including BMP emanating from extra-embryonic ectoderm, that act on cells in the post-implantation epiblast. PGC development can be recapitulated in vitro through the exposure of epiblast-like cells (EpiLCs) to appropriate cytokines, resulting in differentiation into PGC-like cells (PGCLCs). Interestingly, the requirement for cytokines to induce PGCLCs can be bypassed by...
Paper Details
Title
Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry
Published Date
Jun 14, 2021
Journal
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