Smart nanocarrier-based chitosan @silica coated carbon nanotubes composite for breast cancer treatment approach

The nonspecificity of doxorubicin (DOX), as well as its oral bioavailability, is a major obstacle in the clinical setting. This study was based on the change of pH value and designed for the 1st time a novel nano-matrix; multiwall carbon nanotubes (MWCNTs) coated with mesoporous silica (MS) and chitosan (CS). The latter possessed a unique nanostructure with pH-sensitivity in DOX release to be administered orally for the treatment of breast...